Dopamine transporter imaging in autopsy-confirmed Parkinson's disease and multiple system atrophy.
Identifieur interne : 000E07 ( Main/Exploration ); précédent : 000E06; suivant : 000E08Dopamine transporter imaging in autopsy-confirmed Parkinson's disease and multiple system atrophy.
Auteurs : Laura D. Perju-Dumbrava [Autriche] ; Gabor G. Kovacs ; Susanne Pirker ; Kurt Jellinger ; Martha Hoffmann ; Susanne Asenbaum ; Walter PirkerSource :
- Movement disorders : official journal of the Movement Disorder Society [ 1531-8257 ] ; 2012.
English descriptors
- KwdEn :
- Aged, Aged, 80 and over, Autopsy (methods), Cerebellum (radionuclide imaging), Corpus Striatum (radionuclide imaging), Dopamine Plasma Membrane Transport Proteins (metabolism), Female, Humans, Longitudinal Studies, Male, Middle Aged, Multiple System Atrophy (pathology), Multiple System Atrophy (radionuclide imaging), Parkinson Disease (pathology), Parkinson Disease (radionuclide imaging), Retrospective Studies, Tomography, Emission-Computed, Single-Photon.
- MESH :
- chemical , metabolism : Dopamine Plasma Membrane Transport Proteins.
- methods : Autopsy.
- pathology : Multiple System Atrophy, Parkinson Disease.
- radionuclide imaging : Cerebellum, Corpus Striatum, Multiple System Atrophy, Parkinson Disease.
- Aged, Aged, 80 and over, Female, Humans, Longitudinal Studies, Male, Middle Aged, Retrospective Studies, Tomography, Emission-Computed, Single-Photon.
Abstract
Dopamine transporter single-photon emission computerized tomography can visualize dopaminergic degeneration in Parkinson's disease and multiple system atrophy. Some studies have suggested that dopamine transporter imaging can distinguish these disorders based on a more diffuse and symmetric striatal dopamine transporter binding loss in multiple system atrophy. The present study compared patterns of striatal dopamine transporter distribution in postmortem-confirmed Parkinson's disease and multiple system atrophy. Patients with a postmortem diagnosis of multiple system atrophy (n = 6) or Parkinson's disease (n = 8) who had undergone dopamine transporter imaging were included. Imaging had been performed after a mean disease duration of 3.6 and 4.1 years in multiple system atrophy and Parkinson's disease, respectively. Visual analysis showed bilaterally reduced binding in all patients. Mean overall striatal binding was reduced by 53% in multiple system atrophy and 52% in Parkinson's disease. There was a trend for greater asymmetry of striatal binding in multiple system atrophy compared with Parkinson's disease (23% ± 15% vs 10.5% ± 7%, respectively; P = .071), with 3 multiple system atrophy patients showing more asymmetry of striatal binding than any Parkinson's disease patient. Putamen/caudate binding ratios did not differ between the groups. This is the first study comparing dopamine transporter imaging in autopsy-confirmed multiple system atrophy and Parkinson's disease. Unexpectedly, we found a tendency for greater asymmetry of striatal binding in multiple system atrophy than in Parkinson's disease. Our findings demonstrate that these conditions cannot be differentiated by subregional analysis of striatal dopamine transporter binding.
DOI: 10.1002/mds.24000
PubMed: 22102521
Affiliations:
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Kovacs</name></author><author><name sortKey="Pirker, Susanne" sort="Pirker, Susanne" uniqKey="Pirker S" first="Susanne" last="Pirker">Susanne Pirker</name></author><author><name sortKey="Jellinger, Kurt" sort="Jellinger, Kurt" uniqKey="Jellinger K" first="Kurt" last="Jellinger">Kurt Jellinger</name></author><author><name sortKey="Hoffmann, Martha" sort="Hoffmann, Martha" uniqKey="Hoffmann M" first="Martha" last="Hoffmann">Martha Hoffmann</name></author><author><name sortKey="Asenbaum, Susanne" sort="Asenbaum, Susanne" uniqKey="Asenbaum S" first="Susanne" last="Asenbaum">Susanne Asenbaum</name></author><author><name sortKey="Pirker, Walter" sort="Pirker, Walter" uniqKey="Pirker W" first="Walter" last="Pirker">Walter Pirker</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2012">2012</date><idno type="doi">10.1002/mds.24000</idno><idno type="RBID">pubmed:22102521</idno><idno type="pmid">22102521</idno><idno type="wicri:Area/PubMed/Corpus">000F59</idno><idno type="wicri:Area/PubMed/Curation">000F59</idno><idno type="wicri:Area/PubMed/Checkpoint">000E47</idno><idno type="wicri:Area/Ncbi/Merge">003471</idno><idno type="wicri:Area/Ncbi/Curation">003471</idno><idno type="wicri:Area/Ncbi/Checkpoint">003471</idno><idno type="wicri:Area/Main/Merge">000E37</idno><idno type="wicri:Area/Main/Curation">000E07</idno><idno type="wicri:Area/Main/Exploration">000E07</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Dopamine transporter imaging in autopsy-confirmed Parkinson's disease and multiple system atrophy.</title><author><name sortKey="Perju Dumbrava, Laura D" sort="Perju Dumbrava, Laura D" uniqKey="Perju Dumbrava L" first="Laura D" last="Perju-Dumbrava">Laura D. Perju-Dumbrava</name><affiliation wicri:level="3"><nlm:affiliation>Institute of Neurology, Medical University of Vienna, Vienna, Austria.</nlm:affiliation><country xml:lang="fr">Autriche</country><wicri:regionArea>Institute of Neurology, Medical University of Vienna, Vienna</wicri:regionArea><placeName><settlement type="city">Vienne (Autriche)</settlement><region nuts="2" type="province">Vienne (Autriche)</region></placeName></affiliation></author><author><name sortKey="Kovacs, Gabor G" sort="Kovacs, Gabor G" uniqKey="Kovacs G" first="Gabor G" last="Kovacs">Gabor G. Kovacs</name></author><author><name sortKey="Pirker, Susanne" sort="Pirker, Susanne" uniqKey="Pirker S" first="Susanne" last="Pirker">Susanne Pirker</name></author><author><name sortKey="Jellinger, Kurt" sort="Jellinger, Kurt" uniqKey="Jellinger K" first="Kurt" last="Jellinger">Kurt Jellinger</name></author><author><name sortKey="Hoffmann, Martha" sort="Hoffmann, Martha" uniqKey="Hoffmann M" first="Martha" last="Hoffmann">Martha Hoffmann</name></author><author><name sortKey="Asenbaum, Susanne" sort="Asenbaum, Susanne" uniqKey="Asenbaum S" first="Susanne" last="Asenbaum">Susanne Asenbaum</name></author><author><name sortKey="Pirker, Walter" sort="Pirker, Walter" uniqKey="Pirker W" first="Walter" last="Pirker">Walter Pirker</name></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="eISSN">1531-8257</idno><imprint><date when="2012" type="published">2012</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term><term>Aged, 80 and over</term><term>Autopsy (methods)</term><term>Cerebellum (radionuclide imaging)</term><term>Corpus Striatum (radionuclide imaging)</term><term>Dopamine Plasma Membrane Transport Proteins (metabolism)</term><term>Female</term><term>Humans</term><term>Longitudinal Studies</term><term>Male</term><term>Middle Aged</term><term>Multiple System Atrophy (pathology)</term><term>Multiple System Atrophy (radionuclide imaging)</term><term>Parkinson Disease (pathology)</term><term>Parkinson Disease (radionuclide imaging)</term><term>Retrospective Studies</term><term>Tomography, Emission-Computed, Single-Photon</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Dopamine Plasma Membrane Transport Proteins</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Autopsy</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Multiple System Atrophy</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="radionuclide imaging" xml:lang="en"><term>Cerebellum</term><term>Corpus Striatum</term><term>Multiple System Atrophy</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Aged, 80 and over</term><term>Female</term><term>Humans</term><term>Longitudinal Studies</term><term>Male</term><term>Middle Aged</term><term>Retrospective Studies</term><term>Tomography, Emission-Computed, Single-Photon</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Dopamine transporter single-photon emission computerized tomography can visualize dopaminergic degeneration in Parkinson's disease and multiple system atrophy. Some studies have suggested that dopamine transporter imaging can distinguish these disorders based on a more diffuse and symmetric striatal dopamine transporter binding loss in multiple system atrophy. The present study compared patterns of striatal dopamine transporter distribution in postmortem-confirmed Parkinson's disease and multiple system atrophy. Patients with a postmortem diagnosis of multiple system atrophy (n = 6) or Parkinson's disease (n = 8) who had undergone dopamine transporter imaging were included. Imaging had been performed after a mean disease duration of 3.6 and 4.1 years in multiple system atrophy and Parkinson's disease, respectively. Visual analysis showed bilaterally reduced binding in all patients. Mean overall striatal binding was reduced by 53% in multiple system atrophy and 52% in Parkinson's disease. There was a trend for greater asymmetry of striatal binding in multiple system atrophy compared with Parkinson's disease (23% ± 15% vs 10.5% ± 7%, respectively; P = .071), with 3 multiple system atrophy patients showing more asymmetry of striatal binding than any Parkinson's disease patient. Putamen/caudate binding ratios did not differ between the groups. This is the first study comparing dopamine transporter imaging in autopsy-confirmed multiple system atrophy and Parkinson's disease. Unexpectedly, we found a tendency for greater asymmetry of striatal binding in multiple system atrophy than in Parkinson's disease. Our findings demonstrate that these conditions cannot be differentiated by subregional analysis of striatal dopamine transporter binding.</div></front></TEI><affiliations><list><country><li>Autriche</li></country><region><li>Vienne (Autriche)</li></region><settlement><li>Vienne (Autriche)</li></settlement></list><tree><noCountry><name sortKey="Asenbaum, Susanne" sort="Asenbaum, Susanne" uniqKey="Asenbaum S" first="Susanne" last="Asenbaum">Susanne Asenbaum</name><name sortKey="Hoffmann, Martha" sort="Hoffmann, Martha" uniqKey="Hoffmann M" first="Martha" last="Hoffmann">Martha Hoffmann</name><name sortKey="Jellinger, Kurt" sort="Jellinger, Kurt" uniqKey="Jellinger K" first="Kurt" last="Jellinger">Kurt Jellinger</name><name sortKey="Kovacs, Gabor G" sort="Kovacs, Gabor G" uniqKey="Kovacs G" first="Gabor G" last="Kovacs">Gabor G. Kovacs</name><name sortKey="Pirker, Susanne" sort="Pirker, Susanne" uniqKey="Pirker S" first="Susanne" last="Pirker">Susanne Pirker</name><name sortKey="Pirker, Walter" sort="Pirker, Walter" uniqKey="Pirker W" first="Walter" last="Pirker">Walter Pirker</name></noCountry><country name="Autriche"><region name="Vienne (Autriche)"><name sortKey="Perju Dumbrava, Laura D" sort="Perju Dumbrava, Laura D" uniqKey="Perju Dumbrava L" first="Laura D" last="Perju-Dumbrava">Laura D. Perju-Dumbrava</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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